Nowadays, more and more people pay more attentions on their health, well-being and lifespan. If you are interested in aging and longevity innovation, you probably have heard about NMN (Nicotinamide Monoucleotide) which may help improve heart function and improve insulin sensitivity. However Is it safe to take NMN supplement daily? And what is the benefits and potential side effects of using NMN Supplement.

What is NMN (nicotinamide Mononucleotide)

Nicotinamide Mononucleotide (NMN) is a naturally occurring biologically active nucleotide found in various organisms. Commonly used as a raw material for cosmetics, NMN appears as a white to slightly yellow crystalline powder with no distinct odor. Proper storage involves room temperature, dry conditions, and protection from light, ensuring a shelf life of 24 months.

NMN is naturally present in the human body and can also be sourced from certain fruits and vegetables. As niacinamide falls within the vitamin B3 category, NMN is classified as a vitamin B derivative. These derivatives play a vital role in numerous biochemical reactions within the body, closely influencing immunity and metabolism.

Renowned experts in the field, including Dr. David Sinclair, a prominent researcher in aging and longevity from Harvard Medical School, and Dr. Andrew Huberman, a leading neurobiologist and human performance expert affiliated with Stanford University, have significantly contributed to our understanding of NMN's role in health and aging. Dr. Sinclair's groundbreaking work focuses on the molecular mechanisms of aging, while Dr. Huberman's expertise lies in neurobiology and optimizing human performance. Their research enhances our comprehension of the biological significance of NMN and its potential impact on overall well-being.

NMN Benefits

May Boost NAD+ Levels

Early research suggests that taking NMN supplements may help raise NAD+ levels, especially in certain groups. In one recent study with 30 healthy adults, those who took 250 milligrams (mg) of NMN every day for 12 weeks saw their blood NAD+ levels increase significantly compared to those who took a placebo. It's worth noting that both the NMN supplement and the placebo were provided by the company funding the study, which could affect the results.

Another study looked at 80 healthy middle-aged adults who took daily NMN supplements in doses of 300 mg, 600 mg, or 900 mg for 60 days. The findings showed a meaningful increase in blood NAD+ levels, especially in the groups taking 600 mg and 900 mg of NMN per day.

Additionally, NMN has shown promise in raising NAD+ levels in older, overweight adults. While these early results are promising, it's important to remember that more research is needed to confirm and expand on these findings. Despite the potential influence of the study sponsor, current evidence suggests that NMN supplements could be a practical way to boost NAD+ levels in healthy individuals.

Enhancing Athletic Performance and Overall Well-being through NAD+ Boost

The decline in NAD+ levels, crucial for various essential processes like energy production, can negatively impact both your physical well-being and activity levels. Elevating NAD+ levels through the use of NMN supplements has the potential to enhance physical performance and energy levels.

In a study involving 80 middle-aged healthy adults exploring the effects of NMN supplementation, participants underwent a six-minute walking test. Notably, those in the 300 mg, 600 mg, and 900 mg NMN groups exhibited significantly greater walking distances compared to the placebo group at both the 30-day and 60-day marks. The groups receiving 600 mg and 900 mg of NMN demonstrated the longest walking distances, and participants in these NMN groups reported significantly better general health compared to the placebo group.

Furthermore, a study involving 48 middle-aged and younger trained runners revealed that those supplemented with 600 or 1,200 mg of NMN per day for six weeks exhibited improved measures of aerobic capacity compared to the control group. Researchers attributed these improvements to enhanced oxygen utilization in skeletal muscles.

In another study involving 65 men aged 65 and older, those supplemented with 250 mg of NMN for six to 12 weeks experienced significant improvements in gait speed and grip strength compared to the placebo group. However, it's worth noting that this study was funded by the manufacturer of the NMN supplement, raising potential bias concerns. While these findings are promising, larger and independent studies are essential to comprehensively understand how NMN may impact physical performance and overall well-being.

May Lengthen Telomeres
The addition of NMN to your regimen might contribute to the extension of telomeres, the protective "caps" located at the ends of DNA strands. The shortening of telomeres is a key factor in the aging process.

In a study involving both pre-aging mice and eight individuals aged between 45 and 60, a 30-day NMN supplementation period resulted in a significant increase in telomere length in both the mice and the human participants. While this suggests that NMN supplementation could have anti-aging effects through telomere lengthening, it's important to note that more extensive human research is required to fully understand and validate these potential benefits.

Enhancing Metabolic Health through NMN Supplementation
Supplementing with NMN has the potential to improve specific aspects of metabolic health, including the body's responsiveness to insulin, a hormone crucial for transporting blood sugar into cells for energy.

In a small study involving 25 postmenopausal women with prediabetes and excess weight or obesity, the administration of 250 mg of NMN per day for ten weeks resulted in increased skeletal muscle insulin signaling and improved insulin sensitivity compared to a placebo treatment.

Additionally, there is some evidence suggesting that intravenous (IV) NMN treatment may contribute to the reduction of triglyceride levels. However, research on the impact of NMN on blood lipids, blood sugar, and insulin levels in humans is currently limited. Further investigations are needed to fully comprehend the effects of NMN on these crucial metabolic parameters.

NMN Side Effects

Many people may concerned about the side effects of NMN. However, NMN is considered safe, and there is no obvious and significant side effects of NMN have been reported so far.

What is the best does of NMN supplement?

Due to the scarcity of data on NMN supplements, establishing the ideal dosage remains challenging. Studies indicate health benefits ranging from as low as 250 mg to a maximum of 1,200 mg of NMN per day. Only three studies, including those mentioned earlier, have investigated the effects of NMN supplements across various doses. Notably, safety does not seem to vary significantly among different NMN doses.

In a study involving amateur runners, the aerobic advantages of NMN supplementation were more pronounced at higher doses (1,200 mg) compared to lower doses (300 mg). However, there was no observed difference in benefits between a high dose and a medium dose (600 mg).

Conclusion

Many people believed that contend that consuming NMN supplements may have a number of positive health effects. It is a good idea to read the label of any supplements you want to buy to find out exactly what is in them and what testing procedures have been followed. In the meanwhile, it's crucial to discuss your specific condition, potential dangers, and benefits with a healthcare practitioner.

References:

https://www.healthline.com/health/nmn-nicotinamide-mononucleotide-benefits-side-effects-and-dosage

https://www.health.com/nmn-benefits-7550396